Water → HCID 43394298, compound

Participants

Reaction Steps

To a solution of 4-nitrobenzenesulfonyl chloride (512 mg, 2.31 mmol) in CH2Cl2 (8 mL) at room temperature, 4-hydroxypiperidine (404 mg, 4.00 mmol) was added. Triethylamine (0.400 mL, 2.88 mmol) was also added. The mixture was stirred at room temperature overnight. Water and EtOAc were added. The organic phase was separated, washed with 1N HCl, dried over Na2SO4, concentrated in vacuo to give 1-(4-nitrophenylsulfonyl)piperidin-4-ol as a solid (559 mg).

Provenance & Evidence