HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86636614, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 56763813 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 86636614 | HCID 86636614 | 44.9% |
Reaction Steps
A solution of 2,4-dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine (190 mg, 0.94 mmol), cyclobutylamine (0.160 mL, 1.88 mmol) and triethylamine (0.200 mL, 1.44 mmol) in nBuOH (6 mL) was stirred at 70° C. overnight. It was then purified by HPLC to give 2-chloro-N-cyclobutyl-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (100 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258144B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-293c7a9726d94935a6afd7d0c6ce955b |
| Source note | uspto-grants-2012_09 |