HCID 43376334, compound → 2-benzyloxy N-(4-(4-(cyclopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)-N-methylacetamide

HRID 2381693Notes

Reaction equation

HRID 2381693 reaction equation
[CH:1]1([NH:5][C:6]2[C:7]3[CH:31]=[CH:30][NH:29][C:8]=3[N:9]=[C:10](NC3C=CC(S(N4CCC(O)CC4)(=O)=O)=CC=3)[N:11]=2)[CH2:4][CH2:3]C1.[CH2:32]([O:39][CH2:40][C:41]([N:43]([CH3:51])[C:44]1[CH:49]=[CH:48][C:47]([NH2:50])=[CH:46][CH:45]=1)=[O:42])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:32]([O:39][CH2:40][C:41]([N:43]([C:44]1[CH:45]=[CH:46][C:47]([NH:50][C:10]2[N:11]=[C:6]([NH:5][CH:1]3[CH2:4][CH2:3]3)[C:7]3[CH:31]=[CH:30][NH:29][C:8]=3[N:9]=2)=[CH:48][CH:49]=1)[CH3:51])=[O:42])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 43376334HCID 43376334, compoundHCID 444677461-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-ol

Product 1

HCID 668781352-benzyloxy N-(4-(4-(cyclopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)-N-methylacetamide

Procedure

According to the general procedure for synthesis of 1-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-ol, 2-benzoxy-N-methyl-N-(4-aminophenyl)acetamide and 2-Chloro-N-cylclopropyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine gave 2-benzyloxy N-(4-(4-(cyclopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenyl)-N-methylacetamide (MS calcd for C25H26N6O2 442.2, found [MH] 443.5).

Sources & evidence

ORD record
ord-64def5a17acd447b9302fadd51054771
Source dataset
uspto-grants-2012_09
Patent number
US08258144B2

Reaction notes

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