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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2381697Generated: October 31, 2026

4-[(methylsulfonyl)methyl]aniline(SALTDATA: FREE) → 1H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine

https://huagongshe.com/reaction/2381697

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[(methylsulfonyl)methyl]aniline(SALTDATA: FREE)HCID 12843964—
Reactant1-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-olHCID 44467746—
Product1H-Pyrrolo[2,3-d]pyrimidine-2,4-diamineHCID 10351855—

Reaction Steps

According to the general procedure for synthesis of 1-(4-(4-(cyclobutylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)phenylsulfonyl)piperidin-4-ol, 4-(methylsulfonylmethyl)aniline and 2-Chloro-N-cylclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine gave N4-cyclobutyl-N2-(4-methylsulfonylmethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2,4-diamine (MS calcd for C18H21N5O2S 371.5, found [MH] 372.1; UV 205.1, 273.6, 304.5 nm).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08258144B2
Source datasetuspto-grants-2012_09
ORD IDord-79bfba94f21b4b789b0c7ce3bc6fd6d3
Source noteuspto-grants-2012_09