HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzoic Acid → HCID 57990405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzoic Acid | HCID 978 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-chloro-N-cyclopropyl-5-(pyridin-4-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 57990302 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 57990405 | HCID 57990405 | 122.2% |
Reaction Conditions
| Temperature | 135 °C |
|---|
Reaction Steps
A mixture of 2-chloro-N-cyclopropyl-5-(pyridin-4-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (245 mg, 0.557 mmol), 4-aminobenzoic acid (150 mg, 1.09 mmol) and trimethylsilyl chloride (0.300 mL, 2.37 mmol) in nBuOH (4 mL) was stirred at 135° C. for 24 h. It was concentrated in vacuo. The residue was purified by HPLC to give butyl 4-(4-amino-5-(pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate (137 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258144B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-4adc1cf96ce841758a5ab47bf8894d54 |
| Source note | uspto-grants-2012_09 |