Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-BOC-3-Aminopiperidine | HCID 545809 | — |
| Reactant | 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine | HCID 53486828 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86636624 | HCID 86636624 | 72.9% |
Reaction Steps
A mixture of 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (233 mg, 0.681 mmol), 3-amino-1-N-Boc-piperidine (136 mg, 0.680 mmol) and TEA (0.200 mL, 1.44 mmol) in dioxane (5 mL) was stirred at 70° C. for 20 h. Water and EtOAc were added. The organic phase was separated, washed with 1N HCl, then with 5% NaHCO3, dried over Na2SO4, concentrated in vacuo to give tert-butyl 3-(2-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidine-1-carboxylate (251 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08258144B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-c2e52d4b923a42589bd3b2436ab92596 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
