2,4,5-Trichloropyrimidine → 1-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-chloropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

HRID 2381755Notes

Reaction equation

HRID 2381755 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14](F)=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1.[Cl:32]C1N=C(Cl)C(Cl)=CN=1>>[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14]([Cl:32])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 2372592,4,5-TrichloropyrimidineHCID 444673191-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Product 1

HCID 579903921-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-chloropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Procedure

The titled compound was synthesized analogously as compound 1-(4-(4-(4-(4-(aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone, by using 2,4,5-trichloropyrimidine. MS 444.3 and 446.3 (M+H, Cl pattern); UV 210.7, 265.7 nm.

Sources & evidence

ORD record
ord-2e8a7e70acc5474e94fa74fe990b8cee
Source dataset
uspto-grants-2012_09
Patent number
US08258144B2

Reaction notes

Loading…