2-(Piperidin-4-yl)acetamide → 2-(1-(2-(4-(4-Acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-yl)acetamide

HRID 2381758Notes

Reaction equation

HRID 2381758 reaction equation
N[CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[C:14]([F:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][N:26]([C:29](=[O:31])[CH3:30])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[N:10]=2)[CH2:5][CH2:4]1.N1CCC(C[C:39]([NH2:41])=[O:40])CC1>>[C:29]([N:26]1[CH2:27][CH2:28][N:23]([C:20]2[CH:21]=[CH:22][C:17]([NH:16][C:11]3[N:10]=[C:9]([N:6]4[CH2:5][CH2:4][CH:3]([CH2:2][C:39]([NH2:41])=[O:40])[CH2:8][CH2:7]4)[C:14]([F:15])=[CH:13][N:12]=3)=[CH:18][CH:19]=2)[CH2:24][CH2:25]1)(=[O:31])[CH3:30]

Participants

3

Reactant 2

HCID 220649342-(Piperidin-4-yl)acetamideHCID 444673191-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Product 1

HCID 444671662-(1-(2-(4-(4-Acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-yl)acetamide

Procedure

The titled compound was synthesized analogously as compound 1-(4-(4-(4-(4-(aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone, by using 2-(piperidin-4-yl)acetamide. MS 456.3 (M+H); UV 203.8, 269.8 nm.

Sources & evidence

ORD record
ord-1187089a2f1349cca62ac0599094735a
Source dataset
uspto-grants-2012_09
Patent number
US08258144B2

Reaction notes

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