HCID 68494779, compound → HCID 68494206, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-benzyl-5-bromo-3-methylthiophene-2-carboxamide (1.00 g, 3.22 mmol) and copper cyanide (0.72 g, 8.06 mmol) in anhydrous N,N-dimethylformamide (15 mL) was stirred under nitrogen atmosphere at 150° C. for 7 h. The mixture was allowed to cool to ambient temperature, and partitioned between ethyl acetate (150 mL) and 14% aqueous ammonium hydroxide (100 mL). The organic layer was washed with 14% aqueous ammonium hydroxide (75 mL), water (75 mL), dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (0-25% ethyl acetate in hexanes) to afford the title compound as a colorless solid (0.31 g, 37%): 1H NMR (300 MHz, CDCl3) δ 7.41-7.29 (m, 6H), 6.13 (br s, 1H), 4.61 (d, J=5.7 Hz, 2H), 2.50 (s, 3H); MS (ES+) m/z 257.2 (M+1), 279.2 (M+23).

Provenance & Evidence