Benzyl azide → ethyl 2-(1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations as necessary to replace benzylazide with 1-(azidomethyl)-4-fluorobenzene to react with ethyl 2-ethynyl-4-methylthiazole-5-carboxylate, the title compound was obtained as a white solid in 62% yield: 1H NMR (300 MHz, CDCl3) δ 7.98 (s, 1H), 7.32-7.23 (m, 2H), 7.05-6.94 (m, 2H), 5.49 (s, 2H), 4.51 (q, J=7.1 Hz, 2H), 2.62 (s, 3H), 1.29 (t, J=7.1 Hz, 3H); MS (ES+) m/z 347.3 (M+1).

Provenance & Evidence