Benzyl azide → ethyl 4-methyl-2-(1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)thiazole-5-carboxylate

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Reaction Steps

Following the procedure as described in Example 2, making variations as necessary to replace benzylazide with 1-(azidomethyl)-4-(trifluoromethyl)benzene to react with ethyl 2-ethynyl-4-methylthiazole-5-carboxylate, the title compound was obtained as a white solid in 67% yield: 1H NMR (300 MHz, CDCl3) δ 8.03 (s, 1H), 7.66-7.55 (m, 2H), 7.45-7.39 (m, 2H), 4.29 (q, J=7.1 Hz, 2H), 5.62 (s, 2H), 2.66 (s, 3H), 1.32 (t, J=7.1 Hz, 3H); MS (ES+) m/z 397.3 (M+1).

Provenance & Evidence