Benzyl azide → ethyl 2-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations as necessary to replace benzylazide with 1-(2-azidoethyl)-4-fluorobenzene to react with ethyl 2-ethynyl-4-methylthiazole-5-carboxylate, the title compound was obtained as a white solid in 82% yield: 1H NMR (300 MHz, CDCl3) δ 7.87 (s, 1H), 7.09-6.98 (m, 2H), 6.98-6.89 (m, 2H), 4.59 (t, J=7.2 Hz, 2H), 4.30 (q, J=7.1 Hz, 2H), 3.20 (t, J=7.2 Hz, 2H), 2.68 (s, 3H), 1.34 (t, J=7.1 Hz, 3H); MS (ES+) m/z 361.3 (M+1).

Provenance & Evidence