ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate → 4-methyl-2-(1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)thiazole-5-carboxylic acid

HRID 2381811Notes

Reaction equation

HRID 2381811 reaction equation
C(N1C=C(C2SC(C(OCC)=O)=C(C)N=2)N=N1)C1C=CC=CC=1.[CH3:24][C:25]1[N:26]=[C:27]([C:35]2[N:36]=[N:37][N:38]([CH2:40][C:41]3[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][CH:42]=3)[CH:39]=2)[S:28][C:29]=1[C:30]([O:32]CC)=[O:31]>>[CH3:24][C:25]1[N:26]=[C:27]([C:35]2[N:36]=[N:37][N:38]([CH2:40][C:41]3[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:48])[F:49])=[CH:43][CH:42]=3)[CH:39]=2)[S:28][C:29]=1[C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 59179723ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylateHCID 59179724ethyl 4-methyl-2-(1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)thiazole-5-carboxylate

Product 1

HCID 591796824-methyl-2-(1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)thiazole-5-carboxylic acidYield 98%

Procedure

Following the procedure as described in Example 3, making variations as necessary to replace ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate with ethyl 4-methyl-2-(1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazol-4-yl)thiazole-5-carboxylate, the title compound was obtained as a white solid in 98% yield: MS (ES−) m/z 367.2 (M−1).

Sources & evidence

ORD record
ord-389387641c4a443fb35cf11c395708b5
Source dataset
uspto-grants-2012_09
Patent number
US08258160B2

Reaction notes

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