ethyl 2-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate → 2-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylic acid

HRID 2381812Notes

Reaction equation

HRID 2381812 reaction equation
C(N1C=C(C2SC(C(OCC)=O)=C(C)N=2)N=N1)C1C=CC=CC=1.[F:24][C:25]1[CH:48]=[CH:47][C:28]([CH2:29][CH2:30][N:31]2[CH:35]=[C:34]([C:36]3[S:37][C:38]([C:42]([O:44]CC)=[O:43])=[C:39]([CH3:41])[N:40]=3)[N:33]=[N:32]2)=[CH:27][CH:26]=1>>[F:24][C:25]1[CH:48]=[CH:47][C:28]([CH2:29][CH2:30][N:31]2[CH:35]=[C:34]([C:36]3[S:37][C:38]([C:42]([OH:44])=[O:43])=[C:39]([CH3:41])[N:40]=3)[N:33]=[N:32]2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 59179678ethyl 2-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylateHCID 59179723ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate

Product 1

HCID 591796862-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylic acidYield 99%

Procedure

Following the procedure as described in Example 3, making variations as necessary to replace ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate with ethyl 2-(1-(4-fluorophenethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained as a white solid in 99% yield: MS (ES−) m/z 331.2 (M−1).

Sources & evidence

ORD record
ord-117b6c5f2792494e9b62ed741e8af9de
Source dataset
uspto-grants-2012_09
Patent number
US08258160B2

Reaction notes

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