ethyl 2-(1-(2-cyclopropylethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate → 2-(1-(2-cyclopropylethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	ethyl 2-(1-(2-cyclopropylethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate	HCID 59179681	—
Reactant	ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate	HCID 59179723	—
Product	2-(1-(2-cyclopropylethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylic acid	HCID 59179675	89%

Reaction Steps

Following the procedure as described in Example 3, making variations as necessary to replace ethyl 2-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate with ethyl 2-(1-(2-cyclopropylethyl)-1H-1,2,3-triazol-4-yl)-4-methylthiazole-5-carboxylate, the title compound was obtained as a white solid in 89% yield: MS (ES−) m/z 277.2 (M−1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08258160B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-6184ba4f484c4d6693718f3abb366729
Source note	uspto-grants-2012_09