Phenylacetylene → HCID 24957858, compound

Participants

Reaction Steps

Following the procedure as described in Example 10, making variations as necessary to replace phenylacetylene with 4-phenyl-1-butyne to react with 2-azido-N-benzyl-4-methylthiazole-5-carboxamide, the title compound was obtained as a white solid in 20% yield: mp 167-170° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.02 (s, 1H), 7.37-7.19 (m, 10H), 6.15 (t, J=6.0 Hz, 1H), 4.62 (d, J=6.0 Hz, 2H), 3.14-3.02 (m, 4H), 2.67 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 160.9, 155.6, 153.3, 148.5, 140.5, 137.5, 128.9, 128.5, 128.3, 127.8, 126.3, 124.0, 118.6, 44.3, 35.0, 27.2, 17.4; MS (ES+) m/z 404.3 (M+1).

Provenance & Evidence