Phenylacetylene → HCID 24958598, compound

Participants

Reaction Steps

Following the procedure as described in Example 10, making variations as necessary to replace phenylacetylene with 3-ethynylthiophene to react with 2-azido-N-benzyl-4-methylthiazole-5-carboxamide, the title compound was obtained as a white solid in 66% yield: mp 123-126° C. (dichloromethane); 1H NMR (300 MHz, CDCl3) δ 8.49 (s, 1H), 7.82-7.81 (m, 1H), 7.51-7.32 (m, 7H), 6.11 (br s, 1H), 4.63 (d, J=6.0 Hz, 2H), 2.71 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 160.9, 155.4, 153.3, 144.8, 137.4, 130.3, 128.9, 127.9, 127.9, 126.8, 125.7, 124.4, 122.6, 116.4, 44.3, 17.4; MS (ES+) m/z 382.3 (M+1).

Provenance & Evidence