Phenylacetylene → HCID 24958600, compound

Participants

Reaction Steps

Following the procedure as described in Example 10, making variations as necessary to replace phenylacetylene with 1-ethynyl-4-fluorobenzene to react with 2-azido-N-benzyl-4-methylthiazole-5-carboxamide, the title compound was obtained as a white solid in 8% yield: mp 203-205° C. (ethyl acetate/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.77-8.75 (m, 1H), 8.36-8.31 (m, 1H), 7.41-7.16 (m, 8H), 6.10 (br s, 1H), 4.64 (d, J=6.0 Hz, 2H), 2.72 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 161.13, 153.3, 142.3, 137.4, 130.3, 130.2, 129.0, 128.9, 128.2, 128.1, 127.9, 127.9, 124.8, 124.7, 119.8, 119.7, 116.1, 115.8, 44.4, 17.5; MS (ES+) m/z 394.3 (M+1).

Provenance & Evidence