Trifluoroacetic acid → (+)-Cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}ethanoic Acid

Participants

Reaction Steps

640 μl (7.4 mmol) of trifluoroacetic acid were added dropwise to a solution of 300 mg (0.740 mmol) of tert-butyl(+)-cyclopentyl{4-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-ethanoate in 1.5 ml dichloromethane. After 1 h of stirring, the reaction mixture was concentrated under reduced pressure and the residue was dried under high vacuum. This gave 267 mg (100% of theory) of the title compound.

Provenance & Evidence