5-Phenyl-1-pentyne → HCID 59179699, compound

Participants

Reaction Steps

Following the procedure as described in Example 12, making variations as necessary to replace 5-phenyl-1-pentyne with 4-phenyl-1-butyne to react with ethyl 2-azido-4-methylthiazole-5-carboxylate, the title compound was obtained as a white solid in 62% yield: 1H NMR (300 MHz, CDCl3) δ 8.05 (s, 1H), 7.33-7.19 (m, 5H), 4.34 (q, J=7.1 Hz, 2H), 3.17-3.03 (m, 4H), 2.71 (s, 3H), 1.39 (t, J=7.1 Hz, 3H); MS (ES+) m/z 343.3 (M+1).

Provenance & Evidence