3-Pyridinemethanamine → HCID 24958967, compound

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as necessary to replace 4-methyl-2-(4-(3-phenylpropyl)-1H-1,2,3-triazol-1-yl)thiazole-5-carboxylic acid with 4-methyl-2-(4-(2-phenylpropyl)-1H-1,2,3-triazol-1-yl)thiazole-5-carboxylic acid to react with pyridin-3-ylmethanamine, the title compound was obtained as a white solid in 25% yield: mp 114-116° C. (dichloromethane/hexanes); 1H NMR (300 MHz, CDCl3) δ 8.59-8.53 (m, 2H), 8.02 (s, 1H), 7.75-7.72 (m, 1H), 7.33-7.18 (m, 6H), 5.57 (m, 1H), 4.64 (d, J=5.9 Hz, 2H), 3.13-3.02 (m, 4H), 2.67 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 161.2, 155.7, 153.9, 149.0, 148.9, 148.6, 140.5, 135.9, 133.6, 128.5, 128.4, 126.3, 123.8, 123.4, 118.6, 41.7, 35.0, 27.2, 17.5; MS (ES+) m/z 405.1 (M+1).

Provenance & Evidence