Hydrochloric Acid → HCID 68492838, compound

Participants

Reaction Steps

To a solution of ethyl 1-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-1H-1,2,3-triazole-4-carboxylate (0.20 g, 0.54 mmol) in a 1:1 mixture of tetrahydrofuran:water (20 mL) was added lithium hydroxide (0.11 g, 2.69 mmol). The reaction mixture was stirred at ambient temperature for 18 hours, acidified with 10% HCl solution and extracted with dichloromethane (2×50 mL). The organic layer was separated, dried over anhydrous sodium sulphate, filtered and concentrated in vacuo to afford the title compound as a white solid in 53% yield (0.27 g): 1H NMR (300 MHz, DMSO-d6) δ 9.15 (s, 1H), 9.03 (t, J=6.0 Hz, 1H), 7.35-7.22 (m, 5H), 4.46 (d, J=6.0 Hz, 2H), 2.63 (s, 3H); MS (ES+) m/z 344.3 (M+1).

Provenance & Evidence