HCID 68491830, compound → HCID 68492935, compound

HRID 2381849Notes

Reaction equation

HRID 2381849 reaction equation
C(NC(C1SC(N2C=C(C(OCC)=O)N=N2)=NC=1C)=O)C1C=CC=CC=1.[CH2:27]([NH:34][C:35]([C:37]1[S:41][C:40]([N:42]2[C:46]([CH3:47])=[C:45]([C:48]([O:50]CC)=[O:49])[N:44]=[N:43]2)=[N:39][C:38]=1[CH3:53])=[O:36])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:27]([NH:34][C:35]([C:37]1[S:41][C:40]([N:42]2[C:46]([CH3:47])=[C:45]([C:48]([OH:50])=[O:49])[N:44]=[N:43]2)=[N:39][C:38]=1[CH3:53])=[O:36])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 68491830HCID 68491830, compoundHCID 68494694HCID 68494694, compound

Product 1

HCID 68492935HCID 68492935, compoundYield 73%

Procedure

Following the procedure as described in Example 17, making variations as necessary to replace ethyl 1-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-1H-1,2,3-triazole-4-carboxylate with ethyl 1-(5-(benzylcarbamoyl)-4-methylthiazol-2-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylate, the title compound was obtained as a white solid in 73% yield (0.24 g): MS (ES+) m/z 358.3 (M+1).

Sources & evidence

ORD record
ord-a5ce9468778e4c2cb3cadb916668f6ca
Source dataset
uspto-grants-2012_09
Patent number
US08258160B2

Reaction notes

Loading…