HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2381876Generated: October 25, 2026
Dimethyl phenylphosphonite → (3,5-Di-tert-butyl-4-hydroxy-benzyl)-phenyl-phosphinic acid methyl ester
https://huagongshe.com/reaction/2381876
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl phenylphosphonite | HCID 76277 | — |
| Reactant | 2,6-Di-tert-butyl-4-(chloromethyl)phenol | HCID 12378601 | — |
| Product | (3,5-Di-tert-butyl-4-hydroxy-benzyl)-phenyl-phosphinic acid methyl ester | HCID 57909093 | 83% |
Reaction Steps
A mixture of 5 grams (29 mmol) of dimethylphenylphosphonite with 7.5 grams (29 mmol) of 3,5-di-tert-butyl-4-hydroxybenzyl chloride (CAS REG #955-01-1) is heated at 110° C. for 1 hour and cooled to obtain a white solid. The resultant solid is crystallized from 100 mL of hexane to give 9 grams (83% yield) of (3,5-di-tert-butyl-4-hydroxy-benzyl)-phenyl-phosphinic acid methyl ester as a white solid mp 112-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08258253B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-d69dcbc6ba1048338ea803bf42e88474 |
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| Source note | uspto-grants-2012_09 |
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