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HRID2381889

反应详情

EQUATION

反应方程式

HRID 2381889 的结构方程式

REACTANTS

反应物

3
结构：CN=C=O
HCID12228

Methyl isocyanate

C2H3NO

结构：[N-]=[N+]=C1NCN=C1C(N)=O
HCID136377446

未命名化合物

结构：NC(=O)c1nc[nH]c1N
HCID178418703

未命名化合物

PRODUCTS

生成物

1
结构：Cn1nnc2c(C(N)=O)ncn2c1=O
HCID5394

Temozolomide

C6H6N6O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Med. Chem. 1984, 27, 196-201 describes a process wherein 5-amino-1H-imidazole-4-carboxamide is converted into 5-diazo-1H-imidazole-4-carboxamide, which is then cyclised with methylisocyanate in dichloromethane to provide a high yield of temozolomide.