HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2381891Generated: October 26, 2026
Water → 2-Pyridin-3-yl-pyrimidine-5-carboxylic acid methyl ester
https://huagongshe.com/reaction/2381891
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Nicotinamidine hydrochloride | HCID 202042 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3,3-Dimethoxy-2-methoxycarbonylpropen-1-ol | HCID 59117939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Pyridin-3-yl-pyrimidine-5-carboxylic acid methyl ester | HCID 68556527 | 51.2% |
Reaction Steps
To a solution of nicotinamidine hydrochloride (1 g, 6.35 mmol) in anhydrous DMF (12 mL) is added sodium salt of 2-dimethoxymethyl-3-hydroxy-acrylicacid methyl ester (1.46 g, 7.36 mmol) and the reaction mixture is heated at 100° C. under N2 for 3 hours. After this time the reaction is cooled to room temperature and water (48 mL) is added. The precipitate is collected by filtration, washed with water and vacuum dried to afford 2-pyridin-3-yl-pyrimidine-5-carboxylic acid methyl ester (0.7 g, 51%). MS: 216 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08258130B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-e3cc5b4aabe24565a5acffb341a716d4 |
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| Source note | uspto-grants-2012_09 |
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