Hydrochloric Acid → HCID 66710023, compound

Participants

Reaction Steps

86 mg (2.15 mmol) of sodium hydroxide were added to a solution of 120 mg (0.215 mmol) of ethyl cis/trans-1-[4-{[(+)-2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetyl]amino}but-1-en-1-yl]cyclopropanecarboxylate in 0.23 ml of THF and 0.56 ml of ethanol. The suspension was stirred at RT for 20 min and then acidified slightly with 1 N hydrochloric acid. The mixture was extracted three times with ethyl acetate. The combined organic phases were washed with saturated aqueous ammonium chloride solution, dried over magnesium sulfate and concentrated under reduced pressure. This gave 112 mg of the target compound as a cis/trans isomer mixture.

Provenance & Evidence