HCID 68558105, compound → HCID 16093681, compound

Participants

Reaction Steps

To a solution of [benzyloxycarbonyl-(2,3-dihydroxy-propyl)-amino]-acetic acid ethyl ester (1.98 g, 6.37 mmol) in DCM (30 mL) is added NaIO4-impregnated silica (13.04 g). The slurry is stirred rapidly for 4.5 h, and then filtered through a coarse porosity sintered glass funnel. The filtrate is concentrated to afford [benzyloxycarbonyl-(2-oxo-ethyl)-amino]-acetic acid ethyl ester (1.65 g, 92%). MS: 280 (M+H); 1H NMR (300 MHz, CDCl3) δ 9.60-9.68 (m, 1H), 7.26-7.40 (m, 5H), 510-5.19 (m, 2H), 4.00-4.22 (m, 6H), 1.18-1.30 (m, 3H). (see Y.-L. Zhong, T. K. M. Shing J. Org. Chem. 1997, 62 (8), 2622-2624).

Provenance & Evidence