Oxalyl chloride → HCID 86639365, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 5-fluoro-1-{[2-(3-fluorophenyl)-4-methylpyrimidine-5-carbonyl]amino}-1H-indole-3-sulfonic acid (1.06 g) in DCM (60 mL) at 0° C. is added dry DMF (10 drops). Oxalyl chloride (1.05 mL) is added drop wise and the mixture is stirred at 0° C. for 3 h. The mixture is filtered and the collected solid is washed with ether to afford 5-fluoro-1-{[2-(3-fluorophenyl)-4-methylpyrimidine-5-carbonyl]amino}-1H-indole-3-sulfonyl chloride (0.94 g). MS: 461 (M−H)

Provenance & Evidence