Hydrochloric Acid → HCID 68553173, compound

Participants

Reaction Steps

To a slurry of N-[6-(4-fluoro-phenyl)-3-oxo-2,5-dihydro-3H-1,2,4-triazin-4-yl]-acetamide (0.48 g, 1.9 mmol) in MeOH (5 mL) is added 37% aqueous HCl. The mixture is heated to reflux for 3 h, and then cooled to rt. The mixture is basified with 1 M aqueous NaOH to pH ˜12. The resulting precipitate is collected by filtration and dried to afford 4-amino-6-(4-fluoro-phenyl)-4,5-dihydro-2H-1,2,4-triazin-3-one (0.35 g, 88%). MS: 209 (M+H); 1H NMR (300 MHz, DMSO-d6) δ 10.17 (s, 1H), 7.67-7.75 (m, 2H), 7.18-7.29 (m, 2H), 4.75 (s, 2H), 4.45 (s, 2H).

Provenance & Evidence