Lithium Hydroxide → HCID 59200029, compound

Participants

Reaction Steps

3-{2,4-Dioxo-3-[(2-pheyl-pyrimidine-5-carbonyl)-amino]-1,2,3,4-tetrahydro-pyrimidin-5-yl}-propionic acid methyl ester (0.22 mol) is hydrolyzed by LiOH (0.88 mol) in MeOH/water/THF (1:1:1) at rt overnight. MeOH and THF are evaporated in vacuo. The residue is acidified by 5% aqueous HCl. The resulting precipitate is collected and dried to afford 3-{2,4-dioxo-3-[(2-pheyl-pyrimidine-5-carbonyl)-amino]-1,2,3,4-tetrahydro-pyrimidin-5-yl}-propionic acid (40 mg, 48%). MS: 383 (M+H); 1H NMR (300 MHz, CD3OD): δ 2.68-2.77 (m, 2H), 2.98-2.90 (m, 2H), 5.49 (s. N—H), 7.48-7.60 (m, 3H), 8.41-8.56 (m, 2H), 9.32 (s, 2H).

Provenance & Evidence