反应详情

A mixture of [N′-(2-phenyl-pyrimidine-5-carbonyl)-hydrazino]-acetic acid ethyl ester (0.37 mmol) in 25% ammonia solution (25 mL) is stirred at rt over night. The solid is collected by filtration and dried to afford 2-[N′-(2-phenyl-pyrimidine-5-carbonyl)-hydrazino]-acetamide (46%). MS: 272 (M+H); 1H NMR (300 MHz, CD3OD): δ 4.45 (s, 2H), 7.45-7.56 (m, 3H), 8.40-8.50 (m, 2H), 9.18 (s, 2H).

1. filtrationThe solid is collected by filtration
2. customdried