Hexahydrocyclopenta(c)pyrrol-2(1H)-amine → 2-Phenyl-pyrimidine-5-carboxylic acid (hexahydro-cyclopenta[c]pyrrol-2-yl)-amide

Participants

Reaction Steps

Following procedures similar to those of Example 64 but substituting hexahydro-cyclopenta[c]pyrrol-2-ylamine for 3-{3-amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-propionic acid methyl ester, there is prepared 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid (hexahydro-cyclopenta[c]pyrrol-2-yl)-amide (39%) as a solid. MS: 309 (M+H); 1H NMR (300 MHz, CDCl3): δ 1.20-1.90 (m, 6H), 2.40-3.50 (m, 6H), 6.94 (s, N—H), 7.52 (s, 3H), 8.50 (s, 2H), 9.08-9.38 (d, 2H).

Provenance & Evidence