反应详情

Following procedures similar to those of Example 64 but substituting pyrrolidin-1-ylamine hydrochloride for 3-{3-amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-propionic acid methyl ester, there is prepared 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid pyrrolidin 1-yl-amide (67%) as a solid. MS: 269 (M+H); 1H NMR (300 MHz, CDCl3): δ 1.70-2.20 (m, 4H), 2.70-3.46 (m, 4H), 7.55 (s, 3H), 8.42-8.67(m, 2H), 9.14-9.49 (t, 2H).