HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyclopentylpiperazin-1-amine → 2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (4-cyclopentyl-piperazin-1-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyclopentylpiperazin-1-amine | HCID 1512485 | — |
| Reactant | 2-(3-Fluorophenyl)pyrimidine-5-carboxylic acid | HCID 45073363 | — |
| Reactant | 3-Amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-propionic acid methyl ester | HCID 86639370 | — |
| Reactant | 4-Cyclopentyl-piperazin-1-yl-amide | HCID 86639372 | — |
| Product | 2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (4-cyclopentyl-piperazin-1-yl)-amide | HCID 25099393 | — |
Reaction Steps
Following procedures similar to those of Example 64 but using substituting 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid for 2-phenyl-4-yl-pyrimidine-5-carboxylic acid, and substituting 4-cyclopentyl-piperazin-1-ylamine for 3-{3-amino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-propionic acid methyl ester, there is prepared 2-(3-fluoro-phenyl)-pyrimidine-5-carboxylic acid (4-cyclopentyl-piperazin-1-yl-amide (64%) as a solid. MS: 370 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08258130B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-8e25dc5f6a454943b6ae338b0f5b73b2 |
| Source note | uspto-grants-2012_09 |