HCID 25099318, compound → HCID 25099351, compound

Participants

Reaction Steps

A suspended solution of 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (2,3-dihydro-indol-1-yl)-amide (1.00 mmol) and MnO2 (5.00 mmol) in DCM (10 mL) is stirred at rt for 60 min. The reaction mixture is filtered and the filtrate is concentrated in vacuo. The residue is purified by silica gel chromatography eluting with 0-5% methanol in DCM to afford 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid indol-1-ylamide (196 mg, 60%) as a solid. MS: 330 (M+H); 1H NMR (300 MHz, CDCl3): δ 2.77 (s, 3H), 6.58 (s, H), 7.15 (s, 2H), 7.26 (m, 3H), 7.84 (d, H), 8.44 (s, 2H), 8.73 (s, H), 10.94 (br, N—H). IC50=5 nM.

Provenance & Evidence