Pyrrolo[3,2-b]pyridin-1-ylamine → 4-Methyl-2-pyridin-3-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide

Participants

Reaction Steps

Following procedures similar to those of Example 127 but substituting 4-methyl-2-pyridin-3-yl-pyrimidine-5-carboxylic acid for 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid, and substituting 5-fluoro-indol-1-ylamine for pyrrolo[3,2-b]pyridine-1-ylamine, there is prepared 4-methyl-2-pyridin-2-yl-pyrimidine-5-carboxylic acid (5-fluoro-indol-1-yl)-amide (34%) as a solid. MS: 348 (M+H); 1H NMR (300 MHz, CD3OD): δ 2.85 (s, 3H), 6.57 (m, H), 7.02 (m, H), 7.23-7.46 (m, 2H), 7.62 (m, H), 8.70 (d, H), 8.91 (d, H), 9.17 (s, H), 9.63 (s, H).

Provenance & Evidence