反应详情

温度

150 °C

Following procedures similar to those of Example 127, but substituting 5-methoxy-indol-1-ylamine for pyrrolo[3,2-b]pyridine-1-ylamine, and the reaction is stirred at 150° C. for 1 h, there is prepared 2-pyridin-2-yl-pyrimidine-5-carboxylic acid (5-methoxy-indol-1-yl)-amide (22%) as a solid. MS: 360 (M+H); 1H NMR (300 MHz, CD3OD): δ 2.88 (s, 3H), 3.84 (s, 3H), 6.50 (d, H) 6.90 (m, H), 7.13 (d, H), 7.25-7.34 (m, 2H), 7.60 (m, H), 8.05 (m, H), 8.65 (d, H), 8.79 (d, H), 9.20 (s, 2H).