Sodium methanethiolate → HCID 136029932, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(4-methoxy-phenyl)-pyrimidine-5-carboxylic acid (6-methyl-3-oxo-2,5-dihydro-3H-[1,2,4]triazin-4-yl)-amide (100 mg, 0.29 mmol), sodium methanethiolate (206 mg, 2.9 mmol) and DMF (2 mL) is stirred at 110° C. for 6 h., and then cooled to rt. The reaction mixture is concentrated in vacuo, and the residue is purified on a reverse phase HPLC chromatography to afford 2-(4-hydroxy-phenyl)-pyrimidine-5-carboxylic acid (6-methyl-3-oxo-2,5-dihydro-3H-[1,2,4]triazin-4-yl)-amide (32 mg). MS: 327 (M+H); 1H NMR (DMSO-d6): δ 1.87 (s, 3H), 4.17 (s, 2H), 6.74 (m, 2H), 8.21 (d, J=6.9 Hz, 2H), 9.08 (s, 2H), 9.53 (s, 1H).

Provenance & Evidence