Potassium Carbonate → HCID 68556856, compound

Participants

Reaction Steps

A solution of 5-fluoro-3-(1-methoxycarbonyl-1-methyl-ethyl)-indole-1-carboxylic acid tert-butyl ester (5.2 mmol) in MeOH (25 mL) is treated with K2CO3 (720 mg, 5.2 mmol) and heated at reflux for 2 h. The mixture is diluted with brine (50 mL) and extracted with EtOAc (3×50 mL). The combined organic layer is dried (Na2SO4), filtered and concentrated in vacuo to afford 2-(5-fluoro-1H-indol-3-yl)-2-methyl-propionic acid methyl ester (650 mg, 53%, 2 steps), which is used in the next step without further purification. MS: 236 (M+H); 1H NMR (300 MHz, DMSO-d6): δ 7.35 (m, 1H), 7.30 (m, 1H), 7.14 (m, 1H), 6.91 (m, 1H), 3.54 (s, 3H), 1.57 (s, 6H).

Provenance & Evidence