Allyl bromide → HCID 86639381, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2-chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (7 g, 30.7 mmol), allyl bromide (5.26 g, 40.8 mmol) and cesium carbonate (20.8 g, 63.8 mmol) in DMF (280 mL) is heated at 60° C. for 1 h. The reaction is quenched with water, extracted with EtOAC. The organic layer is dried (Na2SO4), filtered and concentrated to afford allyl-(2-chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (8.03 g, 98%), which is sued in the next step with no further purification.

Provenance & Evidence