HCID 25099315, compound → HCID 59200004, compound

Participants

Reaction Steps

A mixture of 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (2-methyl-2,3-dihydro-indol-1-yl)-amide (246 mg, 0.68 mmol) and MnO2 (296 mg, 3.4 mmol) in DCM (10 mL) is stirred at rt for 1.5 h. The reaction mixture is filtered and the filtrate is concentrated in vacuo. The residue is triturated with ether to afford 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (2-methyl-indol-1-yl)-amide (158, 65%). MS: 361 (M+H); 1H NMR (300 MHz, CDCl3): δ 2.39 (s, 3H), 2.83 (s, 3H), 6.36 (s, H), 7.10-7.29 (m, 3H), 7.44-7.62 (m, H), 8.17 (s, H), 8.25 (d, H), 8.35 (d, H), 8.97 (s, H).

Provenance & Evidence