反应详情

LiAlH4 (14.7 mmol, 1 M solution in THF) is added to a solution of 6-fluoro-4H-benzo[1,4]oxazin-3-one (1.23 g, 7.35 mmol) in THF at rt and heated to reflux for 2 hrs. The reaction mixture is quenched with a few drops of water followed by slow addition of ethyl acetate (10 mL). The solid is filtered off, and washed with EtOAc. The filtrate is concentrated in vacuo to afford 6-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine (1 g). MS: 154 (M+H).

1. temperatureheated
2. temperatureto reflux for 2 hrs
3. customThe reaction mixture is quenched with a few drops of water
4. additionfollowed by slow addition of ethyl acetate (10 mL)
5. filtrationThe solid is filtered off
6. washwashed with EtOAc
7. concentrationThe filtrate is concentrated in vacuo