4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride → HCID 59200051, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (529 mg, 2.28 mmol) and 5-fluoro-pyrrolo[2,3-b]pyridin-1-ylamine (288 mg, 1.9 mmol) in DMF (6 mL) is stirred at 40° C. for 1 h. The mixture is treated with DMTMM (524 mg, 1.9 mmol) and stirred at 40° C. for 1 h. The mixture is diluted with saturated aqueous Na2CO3 (5 mL) and stirred for 5 min. The precipitate is collected by filtration and dried in vacuo to afford 2-(3-fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid (5-fluoro-pyrrolo[2,3-b]pyridin-1-yl)-amide (475 mg, 68%). MS: 366 (M+H); 1H NMR (300 MHz, DMSO-d6): δ 9.12 (s, 1H), 8.30 (m, 2H), 8.18 (d, 1H), 7.97 (d, 1H), 7.82 (d, 1H), 7.59 (m, 1H), 7.44 (m, 1H), 6.59 (d, 1H), 2.80 (s, 3H).

Provenance & Evidence