Bromine → HCID 57493956, compound

HRID 2382175Notes

Reaction equation

HRID 2382175 reaction equation
[F:1][C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]([F:10])[C:3]=1[NH2:4].[Br:11]Br>C(O)(=O)C>[Br:11][C:7]1[CH:6]=[C:5]([F:10])[C:3]([NH2:4])=[C:2]([F:1])[C:8]=1[CH3:9]

Participants

4

Reactant 2

HCID 24408BromineHCID 150175362,6-Difluoro-3-methylaniline

Product 1

HCID 57493956HCID 57493956, compoundYield 81.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of 2,6-difluoro-3-methylaniline (5 g, 34.9 mmol) in acetic acid (50 ml) was added dropwise a solution of bromine (1.97 ml, 38.4 mmol) in acetic acid (10 ml) at 55° C. The reaction mixture was stirred for 1 hour and then poured to water/ice. A solid was filtered, washed with water and dried in a vacuum oven. 6.3 g of a black solid were obtained (yield=81%).

Workup

  1. filtrationA solid was filtered
  2. washwashed with water
  3. customdried in a vacuum oven

Sources & evidence

ORD record
ord-68c4fe1053b6492986bbd7207f62c1c7
Source dataset
uspto-grants-2012_09
Patent number
US08258308B2

Reaction notes

Loading…