Methyl bromoacetate → HCID 68771915, compound

Participants

Reaction Steps

To a solution of (3R)-3-methyl-1-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl)piperazine (620 mg, 2.537 mmol) in MeCN was added methyl 2-bromoacetate (466 mg, 3.044 mmol) followed by diisopropylethylamine (0.884 ml, 5.074 mmol). The reaction mixture was stirred at rt for 5 h. The solvent was evaporated under high vacuum and the residue was loaded on column (SiO2, hexane to hexane/EtOAc=100:10 to 100:20 to 100:30 to 100:40) to give methyl 2-((R)-2-methyl-4-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl)piperazin-1-yl)acetate (800 mg, 99.6% yield) as a gum.

Provenance & Evidence