tert-Butyl bromoacetate → HCID 68736144, compound

Participants

Reaction Steps

To a solution of (3R)-3-methyl-1-(2-phenylcyclohexyl)piperazine (900 mg, 3.48 mmol) (crude) in MeCN was added tert-butyl 2-bromoacetate (0.815 g, 4.18 mmol) followed by diisopropylethylamine (1.21 ml, 6.97 mmol). The reaction was stirred at RT for 5 h. The solvent was evaporated under high vacuum and the residue was loaded on column (SiO2, hexane to hexane/EtOAc=100:10 to 100:20 to 100:30 to 100:40) to give tert-butyl 2-((R)-2-methyl-4-(2-phenylcyclohexyl)piperazin-1-yl)acetate (1.16 g, 89.4% yield) as a gum.

Provenance & Evidence