Ethyl bromoacetate → HCID 68735485, compound

Participants

Reaction Steps

To solution of N-phenyl-N-(3-(trifluoromethyl)phenyl)piperidin-4-amine (1.3 g, 4.1 mmol) in MeCN (15 mL) was added ethyl bromoacetate (0.50 ml, 4.5 mmol) followed by triethylamine (1.1 ml, 8.1 mmol). The reaction mixture was stirred at RT for 4 h, diluted with water and extracted with DCM. The combined DCM layer was dried (Na2SO4), and concentrated. The product was purified with ISCO using 0-15% EtOAc in DCM to give ethyl 2-(4-(phenyl(3-(trifluoromethyl)phenyl)amino)piperidin-1-yl)acetate (1.2 g, 73% yield).

Provenance & Evidence