Sodium Hydroxide → HCID 135808011, compound

Participants

Reaction Steps

A mixture of 2-{2-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-acetylamino}-benzamide (432 mg, 1 mmol), 1N sodium hydroxide solution (5 mL) and 1,4-dioxane (5 mL) was stirred a room temperature for 1 day. The reaction mixture was concentrated to approximately half the volume and then neutralized with 1N HCl solution. The product precipitated and was collected by filtration as a white solid (306 mg, 74%). 1H NMR (400 MHz, CDCl3) δ 8.26 (dd, J=8.0, 1.3 Hz, 1H), 7.79 (t, J=8.4 Hz, 1H), 7.73 (dt, J=9.5, 2.5 Hz, 2H), 7.68 (d, J=7.7 Hz, 1H), 7.51 (t, J=8.1 Hz, 1H), 7.08 (dt, J=9.5, 2.4 Hz, 2H), 3.94 (s, 3H), 3.65 (s, 2H), 3.11 (m, 4H), 2.75 (t, J=4.9 Hz, 4H); HPLC ret. time 2.59 min, 10-99% CH3CN, 5 min run; ESI-MS m/z 415.3 (M+1)+.

Provenance & Evidence