Lithium hydroxide, monohydrate → HCID 42641652, compound

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Reaction Steps

To a solution of ethyl 2-(4-(phenyl(4-(trifluoromethyl)phenyl)methyl)piperidin-1-yl)acetate (0.2 g, 0.49 mmol) in THF/MeOH (10 mL, 1:1) was added LiOH.H2O (0.15 g, 3.7 mmol). After stirring at rt for 4 h, the solvent was removed under vacuum. The residue was diluted with water and the pH was adjusted to 3 with diluted HCl, extracted with DCM, and the combined organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum to afford pure 2-(4-(phenyl(4-(trifluoromethyl)phenyl)methyl)piperidin-1-yl)acetic acid (0.07 g, 36% yield) as a white solid. MS (ESI, pos. ion) m/z: 378 (M+1).

Provenance & Evidence